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Target
Leukocyte tyrosine kinase receptor
Ligand
BDBM50448449
Substrate
n/a
Meas. Tech.
ChEMBL_1296026 (CHEMBL3131076)
IC50
10600±n/a nM
Citation
 Shahani, VM; Ball, DP; Ramos, AV; Li, Z; Spagnuolo, PA; Haftchenary, S; Schimmer, AD; Trudel, S; Gunning, PT A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells. Bioorg Med Chem 21:5618-28 (2013) [PubMed]  Article 
Target
Name:
Leukocyte tyrosine kinase receptor
Synonyms:
LTK | LTK_HUMAN | TYK1
Type:
PROTEIN
Mol. Mass.:
91679.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586334
Residue:
864
Sequence:
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGCSEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTAPNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS
  
Inhibitor
Name:
BDBM50448449
Synonyms:
CHEMBL3125667
Type:
Small organic molecule
Emp. Form.:
C26H30FN7O3S
Mol. Mass.:
539.625
SMILES:
NS(=O)(=O)OCCn1cnc2c(Nc3ccc(F)cc3)nc(NCc3ccc(cc3)C3CCCCC3)nc12
Structure:
Search PDB for entries with ligand similarity: