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Target
Kappa-type opioid receptor
Ligand
BDBM50002063
Substrate
n/a
Meas. Tech.
ChEMBL_304044 (CHEMBL840221)
Ki
78±n/a nM
Citation
 Peng, Y; Keenan, SM; Zhang, Q; Kholodovych, V; Welsh, WJ 3D-QSAR comparative molecular field analysis on opioid receptor antagonists: pooling data from different studies. J Med Chem 48:1620-9 (2005) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50002063
Synonyms:
CHEMBL265033
Type:
Small organic molecule
Emp. Form.:
C26H23ClN2O2
Mol. Mass.:
430.926
SMILES:
[H][C@@]12Oc3c4c(CC5N(C)CCC14[C@@]5([H])Cc1cc(cnc21)-c1ccc(Cl)cc1)ccc3O |THB:3:4:13:8.11.10,9:8:13:4.5.6|
Structure:
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