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TargetCytochrome P450 1A
LigandBDBM50041983
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1443697
IC50>50000±n/a nM
Citation Buzard, DJLopez, LMoody, JKawasaki, ASchrader, TOKasem, MJohnson, BZhu, XThoresen, LKim, SHGharbaoui, TSengupta, DCalvano, LKrishnan, AGao, YSemple, GEdwards, JBarden, JMorgan, MUsmani, KChen, CSadeque, AChen, WChristopher, RJThatte, JFu, LSolomon, MWhelan, KAl-Shamma, HGatlin, JGaidarov, IAnthony, TLe, MUnett, DJStirn, SBlackburn, ABehan, DPJones, RM (7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists. ACS Med Chem Lett5:1334-9 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 1A
Name:Cytochrome P450 1A
Synonyms:CYPIA2 | Cytochrome P450 1A2 | Cytochrome P450 1A2 (CYP1A2)
Type:Enzyme
Mol. Mass.:58310.23
Organism:Homo sapiens (Human)
Description:n/a
Residue:515
Sequence:
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN
LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS
DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL
WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE
FSVPPGVKVDLTPIYGLTMKHARCEHVQARRFSIN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50041983
NameBDBM50041983
Synonyms:CHEMBL3359523
TypeSmall organic molecule
Emp. Form.C24H23ClF3NO4
Mol. Mass.481.892
SMILESCC(C)Oc1ccc(COc2ccc3n4CC[C@H](CC(O)=O)c4c(Cl)c3c2)cc1C(F)(F)F |r|
Structure
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n/a