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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50234895
Substrate
n/a
Meas. Tech.
ChEMBL_1654062 (CHEMBL4003428)
IC50
100±n/a nM
Citation
 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Tri- and Tetrasubstituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3. J Med Chem 60:594-607 (2017) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50234895
Synonyms:
CHEMBL4071770
Type:
Small organic molecule
Emp. Form.:
C33H29FN6O2S
Mol. Mass.:
592.686
SMILES:
CSc1nc(c(-c2ccnc(Nc3cccc(NC(=O)c4cccc(NC(=O)C=C)c4C)c3)c2)n1C)-c1ccc(F)cc1
Structure:
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