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Target
Cannabinoid receptor 1
Ligand
BDBM115133
Substrate
n/a
Meas. Tech.
Biological Assay
EC50
2.00±n/a nM
Citation
 Macielag, MJ; Zhang, R; Parker, MH; DeCorte, BL; Greco, MN Indazole derivatives useful as CB-1 inverse agonists US Patent  US9682940 Publication Date 6/20/2017 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM115133
Synonyms:
US9682940, 67
Type:
Small organic molecule
Emp. Form.:
C28H28F3N3O4S
Mol. Mass.:
559.6
SMILES:
COc1ccc(cc1)C(c1ccc(OC)cc1)c1ccc2[nH]nc(C3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1
Structure:
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