86 articles for thisTarget
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Synthesis and biological evaluation of naphthoquinone-coumarin conjugates as topoisomerase II inhibitors.
Instituto Universitario De Bio-Org£Nica (Cibican)
Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIa, G-quadruplex binding and cytotoxic properties.
Universit£
Inhibition of human DNA topoisomerase IIa by two novel ellipticine derivatives.
Vanderbilt University School of Medicine
Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors.
Sun Yat-Sen University
Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents.
Taipei Medical University
Imine/amide-imidazole conjugates derived from 5-amino-4-cyano-N1-substituted benzyl imidazole: Microwave-assisted synthesis and anticancer activity via selective topoisomerase-II-a inhibition.
Central University of Punjab
4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIa targeting the ATP binding site.
National Institute of Chemistry
Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization.
Astrazeneca
Switch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIa Catalytic Inhibitors.
National Institute of Pharmaceutical Education and Research (NIPER)
Monocyclic 4-amino-6-(phenylamino)-1,3,5-triazines as inhibitors of human DNA topoisomerase IIa.
National Institute of Chemistry
Inhibitory activities against topoisomerase I and II by isoaurostatin derivatives and their structure-activity relationships.
Kumamoto University
Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo[d] imidazol-1-yl)acetohydrazide derivatives as antitumor agents.
Sichuan University
Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides.
Stephen F. Austin State University
A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II.
University of Manitoba
Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity.
Osaka University of Pharmaceutical Sciences
Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5-g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition.
Ewha Womans University
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
University of Oxford
Design, synthesis, and biological evaluation of ellipticine-estradiol conjugates.
Purdue University
Catalytic inhibition of eukaryotic topoisomerases I and II by flavonol glycosides extracted from Vicia faba and Lotus edulis.
University of Thessaly
Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases.
University of Cagliari
N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIa and induce apoptosis in G1/S phase.
National Institute of Pharmaceutical Education and Research (NIPER)
Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors.
Sun Yat-Sen University
Role of metalation in the topoisomerase IIa inhibition and antiproliferation activity of a series ofa-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes.
Memorial Sloan-Kettering Cancer Center
A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.
Chinese Academy of Sciences
7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents.
Universit£
The structure-based design, synthesis, and biological evaluation of DNA-binding amide linked bisintercalating bisanthrapyrazole anticancer compounds.
University of Manitoba
Discovery of a new class of catalytic topoisomerase II inhibitors targeting the ATP-binding site by structure based design. Part I.
Novartis Institutes For Biomedical Research
Synthesis, cytotoxic activity, DNA topoisomerase-II inhibition, molecular modeling and structure-activity relationship of 9-anilinothiazolo[5,4-b]quinoline derivatives.
Universidad Nacional AutóNoma De MéXico
The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds.
University of Manitoba
Triterpenoid constituents isolated from the bark of Abies sachalinensis.
Osaka University of Pharmaceutical Sciences
Catalytic inhibition of topoisomerase IIalpha by demethylzeylasterone, a 6-oxophenolic triterpenoid from Kokoona zeylanica.
University of Arizona
Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.
Kumamoto University
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia.
Ohio State University
Discovery and structure-activity relationships of a novel oxazolidinone class of bacterial type II topoisomerase inhibitors.
Redx Anti-Infectives
Novel N-(4-thiocyanatophenyl)-1H-1,2,3-triazole-4-carboxamides exhibit selective cytotoxic activity at nanomolar doses towards human leukemic T-cells.
Ivan Franko National University of Lviv
Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase II? Interactions.
Charles University
Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase II? poison.
Yeungnam University
Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs.
University of Maryland
One pot synthesis, in silico study and evaluation of some novel flavonoids as potent topoisomerase II inhibitors.
Dr. Babasaheb Ambedkar Marathwada University
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors.
National Research Centre
Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer.
Alma Mater Studiorum-Universit£
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
University of Madras
Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II ? over ?.
Istituto Italiano Di Tecnologia
Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors.
Taisho Pharmaceutical
Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives.
University of Belgrade
Synthesis and evaluation of novel sulfonamide analogues of 6/7-aminoflavones as anticancer agents via topoisomerase II inhibition.
Prof John Barnabas Post Graduate School of Biological Studies
Structure-guided optimization of 4,6-substituted-1,3,5-triazin-2(1H)-ones as catalytic inhibitors of human DNA topoisomerase II?.
Slovenia
Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches.
Shandong University
Natural dimers of coumarin, chalcones, and resveratrol and the link between structure and pharmacology.
Nagasaki International University
Probing structural requirements for human topoisomerase I inhibition by a novel N1-Biphenyl fluoroquinolone.
University of Iowa
Design, Synthesis, Dynamic Docking, Biochemical Characterization, and
Istituto Italiano Di Tecnologia
Structure-guided design of antibacterials that allosterically inhibit DNA gyrase.
Glaxosmithkline
Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.
European Biomedical Research Institute of Salerno (Ebris)
Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer.
Colorado State University
Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria.
Chinese Academy of Sciences
Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains.
Alma Mater Studiorum-University of Bologna
Selective Inhibition of Bacterial Topoisomerase I by alkynyl-bisbenzimidazoles.
Clemson University
Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors.
University of Hawai'I At Hilo
Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents.
Universit£
Flavone-based analogues inspired by the natural product simocyclinone D8 as DNA gyrase inhibitors.
Virginia Commonwealth University
3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase II? catalytic inhibitor with low DNA damage.
Ewha Womans University
Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors.
Sun Yat-Sen University
Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity.
National Institute of Pharmaceutical Education and Research
Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships.
University of Illinois At Chicago
Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.
Virginia Polytechnic Institute and State University
Design, synthesis, molecular modeling and anti-proliferative evaluation of novel quinoxaline derivatives as potential DNA intercalators and topoisomerase II inhibitors.
Al-Azhar University
Synthesis and biological evaluation of histone deacetylase and DNA topoisomerase II-Targeted inhibitors.
Kindai University
Design, synthesis, and evaluation of DNA topoisomerase II-targeted nucleosides.
Kyoto University
Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.
Actelion Pharmaceuticals
Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase II?.
Alma Mater Studiorum-University of Bologna
Synthesis, evaluation, and CoMFA study of fluoroquinophenoxazine derivatives as bacterial topoisomerase IA inhibitors.
University of Hawaii At Hilo
Synthesis and biological evaluation of N-(carbobenzyloxy)-l-phenylalanine and N-(carbobenzyloxy)-l-aspartic acid-?-benzyl ester derivatives as potent topoisomerase II? inhibitors.
Hebei University
Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity.
Istituto Italiano Di Tecnologia
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase II? inhibitors and antiproliferative agents.
National and Kapodistrian University of Athens
