PMID

Data

Article Title

Organization

Assessment of the in vivo and in vitro opioid activity of bridged hexahydroaporphine and isoquinoline molecules.

Creighton University

Synthesis and pharmacological evaluation of 4,4-disubstituted piperidines.

Anaquest Pharmaceuticals

Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist.

University of Innsbruck

X-ray crystal structure of the opioid ligand naltrexonazine.

TBA

Probes for narcotic receptor mediated phenomena. 12. cis-(+)-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for delta opioid receptors. Synthesis, absolute configuration, and receptor enantioselectivity.

TBA

Probes for narcotic receptor mediated phenomena. 9. Synthesis of (+/-)-(3 alpha,6a alpha,11a beta)-1,3,4,5,6,11a-hexahydro-2-methyl-2H-3,6a- methanobenzofuro[2,3-c]azocin-10-ol, an oxide-bridged 5-(m-hydroxyphenyl)morphan.

TBA

Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry, biochemistry, and pharmacology.

TBA

3,7-Diazabicyclane: a new narcotic analgesic.

TBA

Irreversible blockage of opioid receptor types by ester homologues of beta-funaltrexamine.

TBA

Acylmorphinans. A novel class of potent analgesic agents.

TBA

Opioid agonists and antagonists. 6-Desoxy-6-substituted lactone, epoxide, and glycidate ester derivatives of naltrexone and oxymorphone.

TBA

Novel nonnarcotic analgesics with an improved therapeutic ratio. Structure-activity relationships of 8-(methylthio)- and 8-(acylthio)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines.

TBA

Synthesis and biological evaluation of 14-alkoxymorphinans. 1. Highly potent opioid agonists in the series of (-)-14-methoxy-N-methylmorphinan-6-ones.

TBA

14 beta-(2-bromoacetamido)morphine and 14 beta-(2-bromoacetamido)morphinone.

TBA

Synthesis and pharmacological studies of 4,4-disubstituted piperidines: a new class of compounds with potent analgesic properties.

TBA

Potential affinity labels for the opiate receptor based on fentanyl and related compounds.

TBA

Common anionic receptor site hypothesis: its relevance to the antagonist action of naloxone.

TBA

Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists.

TBA

Opiate receptor interaction of compounds derived from or structurally related to fentanyl.

TBA

Preparation and analgesic properties of amino acid derivatives of (-)-5,9 alpha-diethyl-2'-hydroxybenzomorphan.

TBA

Synthesis and analgesic activity of some 5-(4-hydroxyphenyl)-2-azabicyclo[3.2.1]octanes.

TBA

Some spiro analogues of the potent analgesic ketobemidone.

TBA

Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor.

Universit£

Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds.

Istituto Superiore Di Sanit£

N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines.

TBA

Chemistry, binding affinities, and behavioral properties of a new class of"antineophobic" mitochondrial DBI receptor complex (mDRC) ligands.

Mayo Foundation

Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo.

TBA

In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.

TBA

Cholecystokinin-A receptor ligands based on the kappa-opioid agonist tifluadom.

Merck Sharp & Dohme Research Laboratories

Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor.

Upjohn