BindingDB BDBM39341 11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one::11-[2-(4-methyl-1-piperazinyl)-1-oxoethyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride::11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride::11-[2-(4-methylpiperazin-1-yl)ethanoyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride::11-[2-(4-methylpiperazino)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride::CHEMBL9967::MLS000069702::PIRENZEPINE::PIRENZEPINE DIHYDROCHLORIDE::SMR000058502::cid

BDBM39341 11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one::11-[2-(4-methyl-1-piperazinyl)-1-oxoethyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride::11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride::11-[2-(4-methylpiperazin-1-yl)ethanoyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride::11-[2-(4-methylpiperazino)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;hydrochloride::CHEMBL9967::MLS000069702::PIRENZEPINE::PIRENZEPINE DIHYDROCHLORIDE::SMR000058502::cid_185248

SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1

InChI Key InChIKey=RMHMFHUVIITRHF-UHFFFAOYSA-N

Data 117 KI 91 IC50 1 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 39341

Muscarinic acetylcholine receptor M1(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)

Ki: 8nMMore data for this Ligand-Target Pair

Reactome pathway
UniProtKB/SwissProt
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Muscarinic acetylcholine receptor M1(RAT)
Mayo Clinic

Curated by PDSP K_i Database

BDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)

Ki: 9nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

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Muscarinic acetylcholine receptor M4(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)

Ki: 28nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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Muscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)

Ki: 150nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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Muscarinic acetylcholine receptor M5(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)

Ki: 170nMMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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Muscarinic acetylcholine receptor M4(RAT)
Mayo Clinic

Curated by PDSP K_i Database

BDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)

Ki: 214nMMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

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Muscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mayo Clinic

Curated by PDSP K_i Database

BDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)

Ki: 270nMMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase CHEMBL DrugBank KEGG PC cid PC sid Similars

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Filter my 209 hits

Targets 12▿
- Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 65
- Muscarinic acetylcholine receptor M1 46
- Muscarinic acetylcholine receptor M2 41
- Muscarinic acetylcholine receptor M4 20
- Muscarinic acetylcholine receptor M3 18
- Muscarinic acetylcholine receptor M5 8
- Muscarinic acetylcholine receptor 3
- Muscarinic receptor M1 2
- Beta-arrestin-1 2
- Muscarinic acetylcholine receptor DM1 2
- Genome polyprotein 1
- Bile salt export pump 1
- ...
Publications 50▿
- J Med Chem 32: 1164-72 (1989) 60
- J Med Chem 57: 9065-77 (2014) 6
- Mol Pharmacol 38: 267-73 (1990) 6
- Mol Pharmacol 38: 805-15 (1990) 6
- J Pharmacol Exp Ther 250: 309-15 (1989) 6
- J Med Chem 42: 356-63 (1999) 5
- J Pharmacol Exp Ther 260: 576-80 (1992) 5
- J Med Chem 56: 1693-703 (2013) 5
- J Pharmacol Exp Ther 256: 727-33 (1991) 5
- J Med Chem 36: 3734-7 (1993) 4
- Bioorg Med Chem 16: 7311-20 (2008) 4
- J Pharmacol Exp Ther 256: 1173-81 (1991) 4
- Bioorg Med Chem Lett 5: 2325-2330 (1995) 4
- J Med Chem 34: 2133-45 (1991) 4
- Mol Pharmacol 35: 469-76 (1989) 4
- Neuron 1: 403-10 (1988) 3
- J Med Chem 31: 1463-6 (1988) 3
- J Med Chem 36: 848-54 (1993) 3
- Pharmacol Toxicol 83: 200-7 (1998) 3
- Annu Rev Pharmacol Toxicol 30: 633-73 (1990) 3
- Bioorg Med Chem Lett 9: 3031-4 (1999) 3
- J Med Chem 38: 473-87 (1995) 3
- J Med Chem 47: 4300-15 (2004) 2
- J Pharmacol Exp Ther 284: 500-7 (1998) 2
- Bioorg Med Chem 15: 7626-37 (2007) 2
- Bioorg Med Chem Lett 6: 785-788 (1996) 2
- Farmaco 58: 739-48 (2003) 2
- J Pharmacol Exp Ther 297: 718-26 (2001) 2
- Eur J Med Chem 92: 221-35 (2015) 2
- J Pharmacol Exp Ther 240: 51-8 (1987) 2
- J Med Chem 32: 1718-24 (1989) 2
- J Agric Food Chem 55: 2276-81 (2007) 2
- J Med Chem 35: 2392-406 (1992) 2
- J Med Chem 31: 1169-74 (1988) 2
- J Med Chem 32: 1522-8 (1989) 2
- J Med Chem 35: 1280-90 (1992) 2
- J Pharmacol Exp Ther 250: 565-72 (1989) 2
- J Pharmacol Exp Ther 257: 1121-9 (1991) 2
- J Med Chem 60: 349-361 (2017) 2
- J Med Chem 34: 2984-9 (1991) 2
- Life Sci 50: 355-63 (1992) 2
- Bioorg Med Chem Lett 7: 979-984 (1997) 2
- Bioorg Med Chem Lett 9: 2795-800 (1999) 1
- J Pharmacol Exp Ther 248: 661-70 (1989) 1
- J Med Chem 30: 1378-82 (1987) 1
- J Med Chem 48: 7847-59 (2005) 1
- J Med Chem 60: 7483-7501 (2017) 1
- Bioorg Med Chem 18: 7675-99 (2010) 1
- Drug Metab Dispos 40: 2332-41 (2012) 1
- PubChem Bioassay (2007) 1
- ...
Institutions 36▿
- University Of Toledo 60
- UniversitÉ 12
- TBA 9
- Universit£ 8
- Mayo Clinic 7
- National Institute of Mental Health 7
- University of Arizona 7
- Glaxo Group Research 6
- University of California 6
- National Institute of Neurological Disorders and Stroke 5
- Warner-Lambert 5
- University Of Arkansas For Medical Sciences 5
- Smithkline Beecham Pharmaceuticals 4
- Dr. Karl Thomae 4
- Alma Mater Studiorum-University Of Bologna 4
- Niddk 4
- University of Bologna 4
- Umr Cnrs/Ulp 7081 3
- Dipartimento Di Scienze Farmaceutiche - Università 3
- National Institute For Medical Research 3
- Nova Pharmaceutical 3
- Uppsala University 3
- Case Western Reserve University 3
- Oak Ridge National Laboratory 3
- Abbott Laboratories 2
- Jagiellonian University Collegium Medicum 2
- Creighton University 2
- Virginia Commonwealth University 2
- Universit&Aagrove 2
- Institute Of Research 2
- The University Of Newcastle 2
- Astrazeneca 1
- University of Pittsburgh 1
- Pfizer 1
- Institute of Science and Technology 1
- Jagiellonian University Medical College 1
- ...
Affinity: 1.1 to 1.0E+6 nM▿
- Ki 117
- IC50 91
- Kd 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1