BDBM50446481 CHEMBL3110004::US10011611, TMP269::US10722597, Compound TMP-269
SMILES FC(F)(F)c1nc(no1)-c1cccc(c1)C(=O)NCC1(CCOCC1)c1nc(cs1)-c1ccccc1
InChI Key InChIKey=HORXBWNTEDOVKN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50446481
Affinity DataKi: 19nMAssay Description:Inhibition of human HDAC9 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Affinity DataKi: 36nMAssay Description:Inhibition of human HDAC7 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Affinity DataKi: 80nMAssay Description:Inhibition of human HDAC5 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Affinity DataKi: 126nMAssay Description:Inhibition of human HDAC4 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of human HDAC6 using p53 residues 379-382 (RHKKAc) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Affinity DataKi: 4.00E+3nMAssay Description:Inhibition of human HDAC8 using p53 residues 379-382 (RHKAcKAc) as substrate as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Affinity DataKi: >1.90E+4nMAssay Description:Inhibition of human HDAC11 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Affinity DataKi: >1.90E+4nMAssay Description:Inhibition of human HDAC2 using p53 (379 to 382 residues) (RHKKAc) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Affinity DataKi: >2.30E+4nMAssay Description:Inhibition of human HDAC1 using p53 (379 to 382 residues) (RHKKAc) as substrate measured after 2 hrs by cheng-Prusoff analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
University Of East Anglia
Curated by ChEMBL
University Of East Anglia
Curated by ChEMBL
Affinity DataKi: >4.30E+4nMAssay Description:Inhibition of human HDAC3/NcoR2 using p53 residues 379-382 (RHKKAc) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair