BDBM7882 1H-imidazole::CHEMBL540::Imidazole (Im)::US9138393, Imidazole::US9144538, Imidazole::imidazole

SMILES c1c[nH]cn1

InChI Key InChIKey=RAXXELZNTBOGNW-UHFFFAOYSA-N

Data  6 KI  7 IC50  2 Kd

PDB links: 123 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 7882   

TargetProstaglandin G/H synthase 1/2(Ovis aries (Sheep))
TBA

Curated by ChEMBL
LigandPNGBDBM7882(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Affinity DataIC50: >1.00E+7nMAssay Description:Inhibition of ram seminal vesicle CyclooxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Wake Forest University Winston-Salem

Curated by ChEMBL
LigandPNGBDBM7882(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of purified mouse inducible nitric oxide synthase catalyzed [14C]-L-citrulline production at a compound concentration of 1 mM in presence ...More data for this Ligand-Target Pair
TargetProstacyclin synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM7882(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Affinity DataIC50:  4.00E+6nMAssay Description:Inhibition of porcine aorta prostacyclin PGI-2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM7882(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Affinity DataIC50:  6.70E+5nMAssay Description:Inhibitory activity against thromboxane A2 synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

LigandPNGBDBM7882(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Affinity DataIC50:  3.52E+5nMAssay Description:Inhibition of recombinant human QC using H-Gln-AMC hydrobromide as fluorogenic substrate incubated for 6 hrs by fluorometric microplate reader analys...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM7882(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Affinity DataIC50: >1.00E+4nMAssay Description:Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM7882(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Affinity DataIC50: >1.00E+4nMAssay Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...More data for this Ligand-Target Pair
In DepthDetails US Patent