BDBM92862 US9284315, BEZ-235::mTOR Inhibitor, BEZ235
SMILES Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1
InChI Key InChIKey=JOGKUKXHTYWRGZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 92862
Affinity DataKi: 1.70nM ΔG°: -12.0kcal/mole IC50: 3.90nMT: 2°CAssay Description:The LanthaScreen TR-FRET mTOR assay was performed using Costar low-binding 284-well plates at room temperature according to the instructions of the m...More data for this Ligand-Target Pair
Affinity DataKi: 2.5nM IC50: 9.60nMAssay Description:The mTOR activity was determined by measuring the amount of [gamma-33 P] phosphae from ATP incorporated in the substrate protein.More data for this Ligand-Target Pair