BDBM195606 NCT-503

SMILES Cc1cc(C)nc(NC(=S)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)c1

InChI Key InChIKey=PJNSZIQUFLWRLH-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 195606   

TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

LigandPNGBDBM195606(NCT-503)
Affinity DataIC50:  2.50E+3nMpH: 8.0 T: 2°CAssay Description:PHGDH assay buffer contained 50 mM TEA pH 8.0, 10 mM MgCl2, 0.05% BSA, and 0.01% Tween-20. PHGDH enzyme buffer consisted of assay buffer with 20 nM P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

LigandPNGBDBM195606(NCT-503)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human liver N-terminal His6-tagged PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3 -phosphoglycerate as substarte measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

LigandPNGBDBM195606(NCT-503)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS assessed as effect on NADH fluorescence incubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

LigandPNGBDBM195606(NCT-503)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

LigandPNGBDBM195606(NCT-503)
Affinity DataEC50:  2.30E+3nMAssay Description:Inhibition of PHGDH in human MDA-MB-468 cells assessed as decrease in serine fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Whitehead Institute For Biomedical Research

LigandPNGBDBM195606(NCT-503)
Affinity DataIC50:  2.50E+3nMAssay Description:Non-competitive inhibition of PHGDH (unknown origin) assessed as reduction in NADH formation using 3-phosphoglycerate as substrate after 20 mins in p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed