BDBM7882 1H-imidazole::CHEMBL540::Imidazole (Im)::US9138393, Imidazole::US9144538, Imidazole::imidazole
SMILES c1c[nH]cn1
InChI Key InChIKey=RAXXELZNTBOGNW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 7882
TargetGamma-aminobutyric acid type B receptor subunit 1(Rattus norvegicus (Rat))
TBA
Curated by PDSP Ki Database
TBA
Curated by PDSP Ki Database
TargetHistamine H3 receptor(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataKi: 1.00E+5nM ΔG°: -5.54kcal/molepH: 8.0 T: 2°CAssay Description:QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...More data for this Ligand-Target Pair
Affinity DataKi: 1.60E+5nM ΔG°: -5.26kcal/molepH: 8.0 T: 2°CAssay Description:QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica
Curated by ChEMBL
Instituto De QuíMica MéDica
Curated by ChEMBL
Affinity DataKi: 1.75E+5nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+7nMAssay Description:Inhibition of ram seminal vesicle CyclooxygenaseMore data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase FKBP5(Homo sapiens (Human))
Boehringer Ingelheim Pharma
Curated by ChEMBL
Boehringer Ingelheim Pharma
Curated by ChEMBL
Affinity DataKd: 4.40E+6nMAssay Description:Binding affinity to 15N-labeled FKBP51 (1 to 140 residues) (unknown origin) expressed in Escherichia coli OD2N by two-dimensional 1H/15N HSQC NMR spe...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Wake Forest University Winston-Salem
Curated by ChEMBL
Wake Forest University Winston-Salem
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of purified mouse inducible nitric oxide synthase catalyzed [14C]-L-citrulline production at a compound concentration of 1 mM in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+6nMAssay Description:Inhibition of porcine aorta prostacyclin PGI-2 synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 6.70E+5nMAssay Description:Inhibitory activity against thromboxane A2 synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 3.52E+5nMAssay Description:Inhibition of recombinant human QC using H-Gln-AMC hydrobromide as fluorogenic substrate incubated for 6 hrs by fluorometric microplate reader analys...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...More data for this Ligand-Target Pair
Affinity DataKd: 5.20E+4nMpH: 7.0Assay Description:Samples for solution resonance Raman spectroscopic studies were prepared withfinal concentrations of 75 μM WT DHP B and 3.75 mM azole in 100 mM ...More data for this Ligand-Target Pair