BDBM100152 7-methoxy-1-methyl-9H-beta-carboline;hydrochloride::7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride::HARMINE::Harmine hydrochloride::MLS002153910::SMR001233259::cid_5359389

SMILES COc1ccc2c(c1)[nH]c1c(C)nccc21

InChI Key InChIKey=BXNJHAXVSOCGBA-UHFFFAOYSA-N

Data  33 KI  155 IC50  5 Kd  1 EC50

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 100152   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 4(Homo sapiens (Human))
Qimr Berghofer Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  8.00E+4nMAssay Description:Inhibition of full-length recombinant human GST-tagged DYRK4 expressed in baculovirus infected insect cells using DYRKtide as substrate after 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Qimr Berghofer Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant GST-tagged DYRK1B (unknown origin) expressed in Escherichia coli using DYRKtide as substrate after 5 mins in presence of [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Qimr Berghofer Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Qimr Berghofer Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  33nMAssay Description:Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation countingMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Homo sapiens (Human))
Qimr Berghofer Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  410nMAssay Description:Inhibition of full-length recombinant human GST-tagged DYRK3 expressed in Escherichia coli using woodtide as substrate after 30 mins in presence of [...More data for this Ligand-Target Pair