BDBM10341 (S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione::1-[(4-methoxyphenyl)methyl]-5-{[(2S)-2-(phenoxymethyl)azetidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione::Azetidine Isatin Analogue 18c

SMILES COc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N2CC[C@H]2COc2ccccc2)cc1

InChI Key InChIKey=LPQXQLRRATZAID-IBGZPJMESA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 10341   

TargetCaspase-3(Homo sapiens (Human))
Washington University

LigandPNGBDBM10341((S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidi...)
Affinity DataIC50:  8.40nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Washington University

LigandPNGBDBM10341((S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidi...)
Affinity DataIC50:  23.2nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Washington University

LigandPNGBDBM10341((S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidi...)
Affinity DataIC50: >5.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University

LigandPNGBDBM10341((S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidi...)
Affinity DataIC50:  8.32nMAssay Description:Inhibition of caspase3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Washington University

LigandPNGBDBM10341((S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidi...)
Affinity DataIC50: >5.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University

LigandPNGBDBM10341((S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidi...)
Affinity DataEC50:  3.07E+3nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Washington University

LigandPNGBDBM10341((S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidi...)
Affinity DataIC50: >5.00E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed