BDBM13523 1,4-diazepan-2-one 2c::4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-2-one::Diazepanone Analog 22

SMILES N[C@@H](CC(=O)N1CCCNC(=O)C1)Cc1cc(F)c(F)cc1F

InChI Key InChIKey=NAFBUDKJGZAEGU-SNVBAGLBSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 13523   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13523(1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-t...)
Affinity DataIC50:  140nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13523(1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-t...)
Affinity DataIC50: >1.00E+5nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13523(1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-t...)
Affinity DataIC50:  4.20E+4nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13523(1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-t...)
Affinity DataIC50:  142nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13523(1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-t...)
Affinity DataIC50: >1.00E+5nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM13523(1,4-diazepan-2-one 2c | 4-[(3R)-3-amino-4-(2,4,5-t...)
Affinity DataIC50:  8.20E+4nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed