BDBM135583 US8846654, 251
SMILES COc1cc(Cn2c(=O)n(C3CCN(CC3)C=O)c3ccc(OC(CF)CF)cc3c2=O)ccc1OCC(=O)N1CCCCC1
InChI Key InChIKey=BBHYMAIPZZCFDD-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 135583
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Sanofi
US Patent
Sanofi
US Patent
Affinity DataIC50: 390nMpH: 7.5Assay Description:By using for PDE8 an enzymatic assay equivalent to that described for PDE7. PDE7 Enzymatic Assay: The assay is carried out in 1.5 ml Eppendorf tube...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Sanofi
US Patent
Sanofi
US Patent
Affinity DataIC50: 46nMpH: 7.5Assay Description:The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...More data for this Ligand-Target Pair