BDBM149916 US8975415, RP197::US9242973, 197

SMILES CC1(C)Oc2ccc(NC(=O)c3ccc(cn3)C#N)cc2C2(COC(N)=N2)C11COC1

InChI Key InChIKey=GPWZMCGYHYETLO-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 149916   

TargetBeta-secretase 1(Homo sapiens (Human))
Comentis

US Patent
LigandPNGBDBM149916(US8975415, RP197 | US9242973, 197)
Affinity DataKi:  72nM IC50:  118nMAssay Description:Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experiments were perfo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Comentis

US Patent
LigandPNGBDBM149916(US8975415, RP197 | US9242973, 197)
Affinity DataKi:  72nM ΔG°:  -9.74kcal/mole IC50:  118nMpH: 4.4 T: 2°CAssay Description:Test Example 1: Potency of test compounds were determined by measurement of their inhibition of BACE1 activity toward a fluorescent substrate. Experi...More data for this Ligand-Target Pair
In DepthDetails US Patent