BDBM16282 2-({2-[(3R)-3-aminopiperidin-1-yl]-6,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile::quinazolinone-based inhibitor 1k

SMILES COc1cc2nc(N3CCC[C@@H](N)C3)n(Cc3ccccc3C#N)c(=O)c2cc1OC

InChI Key InChIKey=PHJKYNSEJIZCAD-QGZVFWFLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16282   

TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM16282(2-({2-[(3R)-3-aminopiperidin-1-yl]-6,7-dimethoxy-4...)
Affinity DataIC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda Pharmaceutical

LigandPNGBDBM16282(2-({2-[(3R)-3-aminopiperidin-1-yl]-6,7-dimethoxy-4...)
Affinity DataIC50:  19nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed