BDBM16590 2-(1H-indazol-3-yl)-1H-1,3-benzodiazole::3-(1H-benzimidazol-2-yl)-1H-indazole::CHEMBL383990::Indazole Compound 2

SMILES c1ccc2[nH]c(nc2c1)-c1n[nH]c2ccccc12

InChI Key InChIKey=JTKFRFMSUBOCIQ-UHFFFAOYSA-N

Data  1 KI  11 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 16590   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Affinity DataKi:  8.58E+3nM ΔG°:  -7.02kcal/molepH: 7.5 T: 2°CAssay Description:For Ki determinations a matrix of inhibitor and substrate concentrations were tested. Inhibitor concentrations were tested from four times IC50 with ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Affinity DataIC50:  845nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Affinity DataIC50:  1.43E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Affinity DataIC50:  744nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Chiron

Curated by ChEMBL
LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Affinity DataIC50: >5.00E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Affinity DataIC50: >2.00E+5nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Mus musculus (mouse))
Chiron

Curated by ChEMBL
LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Affinity DataIC50:  720nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Affinity DataIC50:  6.30E+3nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM16590(2-(1H-indazol-3-yl)-1H-1,3-benzodiazole | 3-(1H-be...)
Affinity DataIC50:  2.71E+3nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed