BDBM17035 (3Z)-5-amino-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one::Indolinone based inhibitor, 3g

SMILES Nc1ccc2NC(=O)\C(=C/c3ccc[nH]3)c2c1

InChI Key InChIKey=ZYTRQJFBKVMEAK-XFFZJAGNSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 17035   

Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17035((3Z)-5-amino-3-(1H-pyrrol-2-ylmethylidene)-2,3-dih...)
Affinity DataIC50:  580nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM17035((3Z)-5-amino-3-(1H-pyrrol-2-ylmethylidene)-2,3-dih...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of FLT3 by ELISA-based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM17035((3Z)-5-amino-3-(1H-pyrrol-2-ylmethylidene)-2,3-dih...)
Affinity DataIC50:  460nMAssay Description:Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM17035((3Z)-5-amino-3-(1H-pyrrol-2-ylmethylidene)-2,3-dih...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of ALK by ELISA-based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM17035((3Z)-5-amino-3-(1H-pyrrol-2-ylmethylidene)-2,3-dih...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of ABL by ELISA-based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed