BDBM178097 4-Acetamido-N-(2-amino-5-fluorophenyl)benzamide (7)::US11377423, Compound 11

SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1cc(F)ccc1N

InChI Key InChIKey=RYYDWFXFHFUPRT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 178097   

TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178097(4-Acetamido-N-(2-amino-5-fluorophenyl)benzamide (7...)
Affinity DataIC50:  153nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178097(4-Acetamido-N-(2-amino-5-fluorophenyl)benzamide (7...)
Affinity DataIC50:  479nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM178097(4-Acetamido-N-(2-amino-5-fluorophenyl)benzamide (7...)
Affinity DataIC50:  106nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178097(4-Acetamido-N-(2-amino-5-fluorophenyl)benzamide (7...)
Affinity DataIC50:  153nMAssay Description:The following non-trypsin coupled in-vitro HDAC enzymatic endpoint assay was used to assay the compounds of the invention. Below is a standardized pr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178097(4-Acetamido-N-(2-amino-5-fluorophenyl)benzamide (7...)
Affinity DataIC50:  479nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM178097(4-Acetamido-N-(2-amino-5-fluorophenyl)benzamide (7...)
Affinity DataIC50:  106nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed