BDBM180805 US9133171, 10::US9133171, 15::US9133171, 16

SMILES COc1cc(F)ccc1-c1nc(Nc2cc(F)cc(CS(C)(=N)=O)c2)ncc1F

InChI Key InChIKey=NSJOYQIOHVHMCZ-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 180805   

TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM180805(US9133171, 10 | US9133171, 15 | US9133171, 16)
Affinity DataIC50:  5nMpH: 8.0 T: 2°CAssay Description:Recombinant full-length His-tagged human CDK9 and CycT1, expressed in insect cells and purified by Ni-NTA affinity chromatography, were purchased fro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM180805(US9133171, 10 | US9133171, 15 | US9133171, 16)
Affinity DataIC50:  6nMpH: 8.0 T: 2°CAssay Description:Recombinant full-length His-tagged human CDK9 and CycT1, expressed in insect cells and purified by Ni-NTA affinity chromatography, were purchased fro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM180805(US9133171, 10 | US9133171, 15 | US9133171, 16)
Affinity DataIC50:  9nMpH: 8.0 T: 2°CAssay Description:Recombinant full-length His-tagged human CDK9 and CycT1, expressed in insect cells and purified by Ni-NTA affinity chromatography, were purchased fro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM180805(US9133171, 10 | US9133171, 15 | US9133171, 16)
Affinity DataIC50:  220nMpH: 8.0 T: 2°CAssay Description:Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sepharose aff...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM180805(US9133171, 10 | US9133171, 15 | US9133171, 16)
Affinity DataIC50:  320nMpH: 8.0 T: 2°CAssay Description:Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sepharose aff...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM180805(US9133171, 10 | US9133171, 15 | US9133171, 16)
Affinity DataIC50:  310nMpH: 8.0 T: 2°CAssay Description:Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sepharose aff...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM180805(US9133171, 10 | US9133171, 15 | US9133171, 16)
Affinity DataIC50:  3.96E+3nMAssay Description:Inhibition of recombinant GST-tagged human CDK2/GST-tagged cyclin E expressed in sf9 cells using biotinylated peptide biotin-Ttds-YISPLKSPYKISEG as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM180805(US9133171, 10 | US9133171, 15 | US9133171, 16)
Affinity DataIC50:  27nMpH: 8.0 T: 2°CAssay Description:Recombinant full-length His-tagged human CDK9 and CycT1, expressed in insect cells and purified by Ni-NTA affinity chromatography, were purchase from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM180805(US9133171, 10 | US9133171, 15 | US9133171, 16)
Affinity DataIC50:  37nMpH: 8.0 T: 2°CAssay Description:Recombinant full-length His-tagged human CDK9 and CycT1, expressed in insect cells and purified by Ni-NTA affinity chromatography, were purchase from...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM180805(US9133171, 10 | US9133171, 15 | US9133171, 16)
Affinity DataIC50: >1.00E+4nMpH: 7.4Assay Description:The principle of the assay is based on the hydrolysis of 4-nitrophenyl acetate by carbonic anhydrases (Pocker & Stone, Biochemistry, 1967, 6, 668), w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM180805(US9133171, 10 | US9133171, 15 | US9133171, 16)
Affinity DataIC50: >1.00E+4nMpH: 7.4Assay Description:The principle of the assay is based on the hydrolysis of 4-nitrophenyl acetate by carbonic anhydrases (Pocker & Stone, Biochemistry, 1967, 6, 668), w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Endotherm

Curated by ChEMBL
LigandPNGBDBM180805(US9133171, 10 | US9133171, 15 | US9133171, 16)
Affinity DataIC50:  37nMAssay Description:Inhibition of recombinant full length His-tagged human CDK9/cyclin T1 expressed in baculovirus expression system using biotinylated peptide biotin-Tt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM180805(US9133171, 10 | US9133171, 15 | US9133171, 16)
Affinity DataIC50:  13nMpH: 8.0 T: 2°CAssay Description:Recombinant full-length His-tagged human CDK9 and CycT1, expressed in insect cells and purified by Ni-NTA affinity chromatography, were purchase from...More data for this Ligand-Target Pair
In DepthDetails US Patent