BDBM18198 1-(cyclopropylmethyl)-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one::7H-[1,4]Oxazino[3,2-g]quinolin-7-one based compound, 12a

SMILES FC(F)(F)c1cc(=O)[nH]c2cc3OCCN(CC4CC4)c3cc12

InChI Key InChIKey=HDJRNXPOUGPQHH-UHFFFAOYSA-N

Data  3 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 18198   

TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18198(1-(cyclopropylmethyl)-9-(trifluoromethyl)-1H,2H,3H...)
Affinity DataKi:  1.60nM ΔG°:  -12.5kcal/mole EC50:  1.40nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18198(1-(cyclopropylmethyl)-9-(trifluoromethyl)-1H,2H,3H...)
Affinity DataKi:  2.00E+3nM ΔG°:  -7.22kcal/molepH: 7.4 T: 2°CAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18198(1-(cyclopropylmethyl)-9-(trifluoromethyl)-1H,2H,3H...)
Affinity DataKi:  8.80E+3nM ΔG°:  -6.41kcal/molepH: 7.4 T: 2°CAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed