BDBM18216 (2R)-2-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-1H,2H,3H,6H,7H-quinolino[7,6-b][1,4]oxazin-7-one::7H-[1,4]Oxazino[3,2-g]quinolin-7-one based compound, (R)-16e::CHEMBL224263

SMILES C[C@@H]1COc2cc3[nH]c(=O)cc(c3cc2N1CC(F)(F)F)C(F)(F)F

InChI Key InChIKey=SPBFNRFRJLBCIQ-SSDOTTSWSA-N

Data  3 KI  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 18216   

TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18216((2R)-2-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluor...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]DHT from human Androgen receptor in human MDA-MB-453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18216((2R)-2-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluor...)
Affinity DataKi:  7.10nM EC50:  1.10nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18216((2R)-2-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluor...)
Affinity DataKi:  7.10nMAssay Description:Agonist activity at androgen receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18216((2R)-2-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluor...)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18216((2R)-2-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluor...)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human androgen receptor in CV1 cells by transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18216((2R)-2-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluor...)
Affinity DataIC50:  70nMAssay Description:Antagonist activity at human androgen receptor in CV1 cells by transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18216((2R)-2-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluor...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed