BDBM185358 US9156831, 9

SMILES CCn1nc(nc1-c1cnc(N)c(n1)-c1nnc(o1)C(C)(C)C)C1CCN(CC1)C(=O)CC(O)=O

InChI Key InChIKey=PPAUWZQIMUAKIA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 185358   

LigandPNGBDBM185358(US9156831, 9)
Affinity DataIC50: <10nMT: 2°CAssay Description:The inhibition of PI3K-beta, PI3K-alpha, PI3K-gamma and PI3K-delta was evaluated in a Kinase Glo based enzyme activity assay using human recombinant ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM185358(US9156831, 9)
Affinity DataIC50:  330nMT: 2°CAssay Description:This assay was used to measure PI3K-alpha inhibition in cells. BT474 cells (human breast ductal carcinoma, ATCC HTB-20) were seeded into black 384 we...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM185358(US9156831, 9)
Affinity DataIC50:  640nMT: 2°CAssay Description:The inhibition of PI3K-beta, PI3K-alpha, PI3K-gamma and PI3K-delta was evaluated in a Kinase Glo based enzyme activity assay using human recombinant ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM185358(US9156831, 9)
Affinity DataIC50: <10nMT: 2°CAssay Description:The inhibition of PI3K-beta, PI3K-alpha, PI3K-gamma and PI3K-delta was evaluated in a Kinase Glo based enzyme activity assay using human recombinant ...More data for this Ligand-Target Pair
In DepthDetails US Patent