BDBM18537 8,8-dimethyl-4-(trifluoromethyl)-1H,2H,8H,9H-pyrido[3,2-g]quinolin-2-one::CHEMBL350877::tricyclic quinoline compound, 1

SMILES CC1(C)Nc2cc3[nH]c(=O)cc(c3cc2C=C1)C(F)(F)F

InChI Key InChIKey=MMLSXRYBGYGQEP-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 18537   

TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18537(8,8-dimethyl-4-(trifluoromethyl)-1H,2H,8H,9H-pyrid...)
Affinity DataKi:  73nM ΔG°:  -10.1kcal/mole IC50:  27nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18537(8,8-dimethyl-4-(trifluoromethyl)-1H,2H,8H,9H-pyrid...)
Affinity DataKi:  86nMAssay Description:Binding affinity for human androgen receptor in transiently-transfected COS-1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18537(8,8-dimethyl-4-(trifluoromethyl)-1H,2H,8H,9H-pyrid...)
Affinity DataIC50:  390nMAssay Description:Antagonistic activity against human progesterone receptor B (hPR-B) in co-transfected CV-1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18537(8,8-dimethyl-4-(trifluoromethyl)-1H,2H,8H,9H-pyrid...)
Affinity DataIC50:  58nMAssay Description:Antagonistic activity against human androgen receptor (hAR) in co-transfected CV-1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed