BDBM198031 US9221795, 27

SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3c(F)ccc(Cl)c3c(=O)n2-c2cccnc2)n1

InChI Key InChIKey=XDSXYMOZKDUASY-INIZCTEOSA-N

Data  5 IC50  8 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 198031   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM198031(US9221795, 27)
Affinity DataIC50:  1nMpH: 7.4Assay Description:Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM198031(US9221795, 27)
Affinity DataIC50:  1nMAssay Description:Inhibition of human full length PI3K p110delta/p85alpha using phosphatidylinositol 3,4,5-trisphosphate as substrate measured after 30 mins by TR-FRET...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM198031(US9221795, 27)
Affinity DataIC50:  750nMAssay Description:Inhibition of human full length PI3K p110alpha/p85alpha using phosphatidylinositol 3,4,5-trisphosphate as substrate measured after 30 mins by TR-FRET...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
LigandPNGBDBM198031(US9221795, 27)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged PI3K p110beta/p85alpha using phosphatidylinositol 3,4,5-trisphosphate as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
LigandPNGBDBM198031(US9221795, 27)
Affinity DataIC50:  190nMAssay Description:Inhibition of human full length PI3K p110gamma using phosphatidylinositol 3,4,5-trisphosphate as substrate measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM198031(US9221795, 27)
Affinity DataEC50:  1nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM198031(US9221795, 27)
Affinity DataEC50:  2.40nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as inhibition of BCR-induced B-cell activationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM198031(US9221795, 27)
Affinity DataEC50:  1.17E+3nMAssay Description:Inhibition of PI3K p110alpha in mouse embryonic fibroblast cells assessed as reduction in PDGF-induced AKT phosphorylation at S473 residue preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
LigandPNGBDBM198031(US9221795, 27)
Affinity DataEC50:  42nMAssay Description:Inhibition of PI3K p110beta in human PC-3 cells assessed as reduction in AKT phosphorylation at S473 residue measured after 2 hrs by TR-FRET analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
LigandPNGBDBM198031(US9221795, 27)
Affinity DataEC50:  404nMAssay Description:Inhibition of PI3K p110gamma in human basophil assessed as reduction in fMLP-induced basophil activation by flow cytometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM198031(US9221795, 27)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of PI3K p110delta in human basophil assessed as reduction in anti-FCepsilonR1 mAb-induced basophil activation preincubated for 60 mins fol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM198031(US9221795, 27)
Affinity DataEC50:  581nMAssay Description:Inhibition of PI3K p110gamma in human basophil assessed as reduction in fMLP-induced basophil activation in presence of 25% serum by flow cytometry a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM198031(US9221795, 27)
Affinity DataEC50:  0.310nMAssay Description:Inhibition of PI3K p110delta in human basophil assessed as reduction in anti-FCepsilonR1 mAb-stimulated basophil activation preincubated for 60 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB