BDBM198665 US9221796, 2b
SMILES Oc1ccc(cc1)C1CCN(CC1)[C@@H]1CCN(Cc2ccc(F)cc2)C1=O
InChI Key InChIKey=KOQYBHVHTCKDIZ-OAQYLSRUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 198665
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataKi: 1.40nM ΔG°: -13.1kcal/moleT: 2°CAssay Description:To perform the competition binding assay, thawed membrane homogenate was
added to each well of a 96-well plate (20 ug/well). The experimental
compo...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Binding affinity to GluN2B receptor in human cortexMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Research And Development
Curated by ChEMBL
Affinity DataIC50: 620nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as reduction in peak tail current after 2 to 5 mins by patch clamp based electrophysiology...More data for this Ligand-Target Pair