BDBM202365 US9238626, (+)-(Ib) HCl
SMILES CC1=C[C@@H]2C[C@H](C1)c1c(C2)nc2cc(Cl)ccc2c1NCCCCCCCCCNC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
InChI Key InChIKey=VZYCFKMNVCPCHV-IKOFQBKESA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 202365
Affinity DataIC50: 265nMpH: 8.0 T: 2°CAssay Description:BChE inhibitory activity determinations were carried out similarly by
the method of Ellman et al., using 0.02 unit/mL of human serum BChE and
300 u...More data for this Ligand-Target Pair
Affinity DataIC50: 2.93E+3nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity of compounds (Ia)-(Ie) and (-)-(Ib) and
(+)-(Ib) was evaluated spectrophotometrically at 25° C. by the
method of Ellma...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universitat De Barcelona
US Patent
Universitat De Barcelona
US Patent
Affinity DataIC50: 98.9nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity of compounds (Ia)-(Ie) and (-)-(Ib) and
(+)-(Ib) was evaluated spectrophotometrically at 25° C. by the
method of Ellma...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMT: 2°CAssay Description:β-Secretase (BACE-1, Sigma) inhibition studies were performed
by employing a peptide mimicking APP sequence as substrate
(methoxycoumarin-Ser-...More data for this Ligand-Target Pair