BDBM202365 US9238626, (+)-(Ib) HCl

SMILES CC1=C[C@@H]2C[C@H](C1)c1c(C2)nc2cc(Cl)ccc2c1NCCCCCCCCCNC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1

InChI Key InChIKey=VZYCFKMNVCPCHV-IKOFQBKESA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 202365   

TargetCholinesterase(Homo sapiens (Human))
Universitat De Barcelona

US Patent
LigandPNGBDBM202365(US9238626, (+)-(Ib) HCl)
Affinity DataIC50:  265nMpH: 8.0 T: 2°CAssay Description:BChE inhibitory activity determinations were carried out similarly by the method of Ellman et al., using 0.02 unit/mL of human serum BChE and 300 u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

US Patent
LigandPNGBDBM202365(US9238626, (+)-(Ib) HCl)
Affinity DataIC50:  2.93E+3nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity of compounds (Ia)-(Ie) and (-)-(Ib) and (+)-(Ib) was evaluated spectrophotometrically at 25° C. by the method of Ellma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Universitat De Barcelona

US Patent
LigandPNGBDBM202365(US9238626, (+)-(Ib) HCl)
Affinity DataIC50:  98.9nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity of compounds (Ia)-(Ie) and (-)-(Ib) and (+)-(Ib) was evaluated spectrophotometrically at 25° C. by the method of Ellma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Universitat De Barcelona

US Patent
LigandPNGBDBM202365(US9238626, (+)-(Ib) HCl)
Affinity DataIC50:  80nMT: 2°CAssay Description:β-Secretase (BACE-1, Sigma) inhibition studies were performed by employing a peptide mimicking APP sequence as substrate (methoxycoumarin-Ser-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent