BDBM205429 (R)-JQ1 (3)::US10407441, Compound (R)-JQ1::US10925881, Name (R)-JQ1::US11028051, Cmpd (+)-JQ1::US11117865, Compound JQ1::US11306105, Compound JQ1::US11406645, Compound JQ1::US11542273, Example (+)-JQ1::US11890288, Compound (+)-JQ1::US9320741, (R)-JQ1

SMILES Cc1nnc2[C@@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1

InChI Key InChIKey=DNVXATUJJDPFDM-QGZVFWFLSA-N

Data  26 IC50  16 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 205429   

TargetBromodomain-containing protein 2 [71-194](Homo sapiens (Human))
Dana-Farber Cancer Institute

LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  27nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2 [71-194,348-455](Homo sapiens (Human))
Dana-Farber Cancer Institute

LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  5.60nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 3 [24-144](Homo sapiens (Human))
Dana-Farber Cancer Institute

LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  14nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 3 [306-416](Homo sapiens (Human))
Dana-Farber Cancer Institute

LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  19nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 3 [24-144,306-416](Homo sapiens (Human))
Dana-Farber Cancer Institute

LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  14nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [44-168](Homo sapiens (Human))
Dana-Farber Cancer Institute

LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  14nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [333-460](Homo sapiens (Human))
Dana-Farber Cancer Institute

LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  8.20nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [44-168,333-460](Homo sapiens (Human))
Dana-Farber Cancer Institute

LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  7.30nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform C of Bromodomain-containing protein 4 (Short)(Homo sapiens (Human))
Dana-Farber Cancer Institute

LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  11nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain testis-specific protein [21-137](Homo sapiens (Human))
Dana-Farber Cancer Institute

LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  47nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain testis-specific protein [251-382](Homo sapiens (Human))
Dana-Farber Cancer Institute

LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  35nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain testis-specific protein [21-137,251-382](Homo sapiens (Human))
Dana-Farber Cancer Institute

LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  46nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  49nMAssay Description:Inhibition of human BRD4 bromodomain1 expressed in BL21(DE3) cells by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2 [74-94](Homo sapiens (Human))
St. Jude Children'S Research Hospital

US Patent
LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  89nMAssay Description:Binding of compounds to BRD2 was monitored using an ITC200 (Microcal, Piscataway, N.J.). Either Brd2.1 (74-194) or Brd2.2 (348-455) was dialyzed over...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [348-455](Homo sapiens (Human))
St. Jude Children'S Research Hospital

US Patent
LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  112nMAssay Description:Binding of compounds to BRD2 was monitored using an ITC200 (Microcal, Piscataway, N.J.). Either Brd2.1 (74-194) or Brd2.2 (348-455) was dialyzed over...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [348-455](Homo sapiens (Human))
St. Jude Children'S Research Hospital

US Patent
LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataKd:  18nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed