BDBM21220 (2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide::Adenosine analog, 3::Adenosine, N6-Ethyl-carboxamido::Adenosine-5-(N-ethylcarboxamide)::CHEMBL464859::N-Ethylcarboxamidoadenosine::NECA
SMILES CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
InChI Key InChIKey=JADDQZYHOWSFJD-FLNNQWSLSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 83 hits for monomerid = 21220
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Affinity DataEC50: 17.6nMAssay Description:Agonist activity at human adenosine A2A receptor expressed in CHO-K1 cells by cAMP accumulation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 10.2nMAssay Description:Agonist activity at human recombinant adenosine receptor-1 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production prei...More data for this Ligand-Target Pair
Affinity DataEC50: 260nMAssay Description:Stimulation of adenylate cyclase activity in human platelet membrane at A2 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.51E+3nMAssay Description:Agonist activity at human adenosine receptor A2B expressed in CHO cell membranes assessed as forskolin-stimulated cAMP accumulation preincubated for ...More data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Agonist activity at human A2BAR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 min...More data for this Ligand-Target Pair
Affinity DataEC50: 0.759nMAssay Description:Agonist activity at human A1AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Affinity DataEC50: 3.30nMAssay Description:Agonist activity at human A2A-AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 40 mi...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 14nMAssay Description:Agonist activity at human A3AR expressed in FlpIn-CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation preincubated for 10 mins...More data for this Ligand-Target Pair
Affinity DataEC50: 0.437nMAssay Description:Agonist activity at human A1AR expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4 dye-based fluorescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 32nMAssay Description:Agonist activity at Homo sapiens (human) adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Affinity DataEC50: 251nMAssay Description:Agonist activity at Homo sapiens (human) adenosine A2a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 63nMAssay Description:Agonist activity at Homo sapiens (human) adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 316nMAssay Description:Agonist activity at Homo sapiens (human) adenosine A2b receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 140nMAssay Description:Agonist activity at human A2B adenosine receptor by cell based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.120nMAssay Description:Agonist activity at human A1A adenosine receptor expressed in HEK cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity at human A1A adenosine receptor expressed in CHOKI cells assessed as induction of beta-arrestin2 recruitment after 60 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 188nMAssay Description:Partial agonist activity at recombinant mouse A3AR expressed in HEK293 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured afte...More data for this Ligand-Target Pair
Affinity DataEC50: 0.501nMAssay Description:Irreversible agonist activity at human adenosine A1 receptor expressed in Flp-In-CHO cells assessed as stimulation of ERK1/2 phosphorylation incubate...More data for this Ligand-Target Pair
Affinity DataEC50: 1.60nMAssay Description:Irreversible agonist activity at human adenosine A1 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation ...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Affinity DataEC50: 2.5nMAssay Description:Irreversible agonist activity at human adenosine A2A receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation...More data for this Ligand-Target Pair
Affinity DataEC50: 43nMAssay Description:Irreversible agonist activity at human adenosine A2B receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 16nMAssay Description:Irreversible agonist activity at human adenosine A3 receptor expressed in Flp-In-CHO cells assessed as effect on forskolin-induced cAMP accumulation ...More data for this Ligand-Target Pair
Affinity DataEC50: 95nMAssay Description:Agonist activity at recombinant human A2BAR expressed in CHO cells assessed as stimulation of cAMP formation preincubated for 30 mins in presence of ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.80nMAssay Description:Antagonist activity at human wild type A1R expressed in CHO-K1 cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measur...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 0.117nMAssay Description:Antagonist activity at human wild type A3R expressed in Flp-In-CHO cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by me...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Affinity DataEC50: 11nMAssay Description:Agonist activity at human adenosine A2A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated fo...More data for this Ligand-Target Pair
Affinity DataEC50: 63nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated fo...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 15nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at human A1 receptor expressed in Flp-In-CHO cells assessed as inhibition of forskolin stimulated cAMP accumulation incubated for 30...More data for this Ligand-Target Pair
Affinity DataEC50: 4.90nMAssay Description:Agonist activity at human A1 receptor expressed in Flp-In-CHO cells assessed as stimulation of calcium mobilization by calcium mobilization assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Affinity DataEC50: 4.80nMAssay Description:Agonist activity at human A2A receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.80nMAssay Description:Agonist activity at human A2B receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 10 mins in presence of forskolin by ...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 48nMAssay Description:Agonist activity at human A3 receptor expressed in Flp-In-CHO cells assessed as cAMP accumulation incubated for 30 mins in presence of forskolin by L...More data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins by LANCE cAMP assayMore data for this Ligand-Target Pair
Affinity DataEC50: 331nMAssay Description:Agonist activity at A2BR in human NHVCF cells assessed as cAMP accumulation incubated for 30 mins in presence of PSB603 by LANCE cAMP assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 177nMAssay Description:Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as beta arrestin 2 recruitment potency by luciferase based...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 154nMAssay Description:Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based Na...More data for this Ligand-Target Pair
Affinity DataEC50: 140nMAssay Description:Binding affinity of ligand at human adenosine receptors expressed in CHO cell. More data for this Ligand-Target Pair
TargetAdenosine receptor A1(Rattus norvegicus (rat))
UniversitÄT Heidelberg
Curated by PDSP Ki Database
UniversitÄT Heidelberg
Curated by PDSP Ki Database
Affinity DataEC50: 55nMAssay Description:Adenosine A1 receptor mediated negative chronotropic activity in spontaneously beating rat atriaMore data for this Ligand-Target Pair
Affinity DataEC50: 394nMAssay Description:Vasorelaxation as Adenosine A2A receptor activity in rat aortaMore data for this Ligand-Target Pair
TargetAdenosine receptor A1(Rattus norvegicus (rat))
UniversitÄT Heidelberg
Curated by PDSP Ki Database
UniversitÄT Heidelberg
Curated by PDSP Ki Database
Affinity DataEC50: 5.48E+4nMAssay Description:Functional activity against adenosine A1 receptor from rat atria.More data for this Ligand-Target Pair
TargetAdenosine receptor A1(Rattus norvegicus (rat))
UniversitÄT Heidelberg
Curated by PDSP Ki Database
UniversitÄT Heidelberg
Curated by PDSP Ki Database
Affinity DataEC50: 55nMAssay Description:Negative chronotropic activity via A1 Adenosine receptor was tested in spontaneously beating rat atriaMore data for this Ligand-Target Pair
Affinity DataEC50: 7.14E+6nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclaseMore data for this Ligand-Target Pair
Affinity DataEC50: 330nMAssay Description:Agonist activity at human recombinant adenosine receptor A2b by cAMP assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 350nMAssay Description:Agonist activity at human adenosine A3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Affinity DataEC50: 13nMAssay Description:Agonist activity at human adenosine A2A receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of [3H]cAMP levels by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at human Adenosine A1 receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphai1 after 16 hrs by beta galactosidase r...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Glaxowellcome Medicines Research Centre
Curated by ChEMBL
Affinity DataEC50: 339nMAssay Description:Agonist activity at human Adenosine A2A receptor expressed in yeast cells coexpressed with chimeric GPA1/Galphas after 16 hrs by beta-galactosidase r...More data for this Ligand-Target Pair