BDBM22030 (2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)propyl]-5-{[(E)-imino(nitroamino)methyl]amino}pentanamide::(2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)propyl]-5-{[(Z)-imino(nitroamino)methyl]amino}pentanamide::(2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)propyl]-5-{[imino(nitroamino)methyl]amino}pentanamide::(2S)-2-amino-N-[(1S)-3-amino-1-carbamoylpropyl]-5-(1-nitrocarbamimidamido)pentanamide::CHEMBL1204421::CHEMBL44833::CHEMBL481413::JMC522060 Compound 1::L-Arg NO2-L-Dbu-NH2::L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRIC AMIDE::L-Nomega-nitroarginine-2,4-L-diaminobutyramide::dipeptide amide inhibitor I

SMILES NCC[C@H](NC(=O)[C@@H](N)CCCN=C(N)N[N+]([O-])=O)C(N)=O

InChI Key InChIKey=KUZKVXUOMSVPOA-BQBZGAKWSA-N

Data  27 KI

PDB links: 5 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 22030   

TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  130nMAssay Description:Inhibitory activity against Neuronal Nitric Oxide Synthase (nNOS)More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  130nMAssay Description:Nitric Oxide Synthase Inhibitory activity tested against bovine brain nNOS (Neuronal nitric oxide synthase)More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  130nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  130nMAssay Description:Inhibitory activity against recombinant rat nNOS.More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  130nMAssay Description:Binding affinity towards neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  130nMAssay Description:Binding affinity against bovine brain nNOS (neuronal).More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  130nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  130nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  300nM ΔG°:  -9.04kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  300nM ΔG°:  -9.04kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  330nMAssay Description:Inhibitory activity against neuronal nitric oxide synthaseChecked by AuthorMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial [N368D](Bos taurus (bovine))
University of California Irvine

LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  9.50E+3nM ΔG°:  -6.96kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  2.50E+4nMAssay Description:Binding affinity against recombinant murine Inducible nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  2.50E+4nMAssay Description:Nitric Oxide Synthase Inhibitory activity tested against recombinant murine Inducible nitric oxide synthase (inducible isoform)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  2.50E+4nMAssay Description:Binding affinity towards inducible nitric oxide synthase (iNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibitory activity against recombinant murine iNOS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain [D597N](Rattus norvegicus (rat))
University of California Irvine

LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  6.70E+4nM ΔG°:  -5.79kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  9.70E+4nMAssay Description:Inhibitory activity against Inducible nitric oxide synthaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
University of California Irvine

LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  1.07E+5nM ΔG°:  -5.50kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
University of California Irvine

LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  1.07E+5nM ΔG°:  -5.50kcal/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
University of California Irvine

LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  2.00E+5nMAssay Description:Nitric Oxide Synthase Inhibitory activity tested against recombinant bovine eNOS (Endothelial nitric oxide synthase)More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
University of California Irvine

LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  2.00E+5nMAssay Description:Inhibitory activity against recombinant bovine eNOS.More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
University of California Irvine

LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  2.00E+5nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
University of California Irvine

LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  2.00E+5nMAssay Description:Binding affinity towards endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
University of California Irvine

LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  2.00E+5nMAssay Description:Binding affinity against recombinant bovine Endothelial nitric oxide synthase.More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  2.45E+5nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase (eNOS)Checked by AuthorMore data for this Ligand-Target Pair