BDBM22818 5-bromo-1-(2-methylprop-2-en-1-yl)-2,3-dihydro-1H-indole-2,3-dione::Isatin-based compound, 38

SMILES CC(=C)CN1C(=O)C(=O)c2cc(Br)ccc12

InChI Key InChIKey=RUGKDKWVOXRCGI-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 22818   

TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22818(5-bromo-1-(2-methylprop-2-en-1-yl)-2,3-dihydro-1H-...)
Affinity DataKi:  66nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
St. Jude Research Hospital

LigandPNGBDBM22818(5-bromo-1-(2-methylprop-2-en-1-yl)-2,3-dihydro-1H-...)
Affinity DataKi:  130nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22818(5-bromo-1-(2-methylprop-2-en-1-yl)-2,3-dihydro-1H-...)
Affinity DataKi:  280nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22818(5-bromo-1-(2-methylprop-2-en-1-yl)-2,3-dihydro-1H-...)
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22818(5-bromo-1-(2-methylprop-2-en-1-yl)-2,3-dihydro-1H-...)
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed