BDBM2339 Pyrrolyl Aryl Sulfone (PAS) 3::Pyrrolyl Aryl Sulfone (PAS) 8d::ethyl 1-[(2-amino-5-chlorobenzene)sulfonyl]-1H-pyrrole-2-carboxylate

SMILES CCOC(=O)c1cccn1S(=O)(=O)c1cc(Cl)ccc1N

InChI Key InChIKey=SMNXJEBYPOVRHP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 2339   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Universita Di Roma

LigandPNGBDBM2339(Pyrrolyl Aryl Sulfone (PAS) 3 | Pyrrolyl Aryl Sulf...)
Affinity DataIC50:  400nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Universita Di Roma

LigandPNGBDBM2339(Pyrrolyl Aryl Sulfone (PAS) 3 | Pyrrolyl Aryl Sulf...)
Affinity DataIC50:  7.50E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Universita Di Roma

LigandPNGBDBM2339(Pyrrolyl Aryl Sulfone (PAS) 3 | Pyrrolyl Aryl Sulf...)
Affinity DataIC50:  400nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [613-1167,R896S,E946D,S1117V]/[618-1043,R896S,E946D](Human immunodeficiency virus type 2)
Universita Di Roma

LigandPNGBDBM2339(Pyrrolyl Aryl Sulfone (PAS) 3 | Pyrrolyl Aryl Sulf...)
Affinity DataIC50: >2.00E+4nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
Universita Di Roma

LigandPNGBDBM2339(Pyrrolyl Aryl Sulfone (PAS) 3 | Pyrrolyl Aryl Sulf...)
Affinity DataIC50:  8.50E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed