BDBM234958 US9556148, 25::n-(cyanomethyl)-4-(2-((4-(4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)benzamide

SMILES Cc1nnc(o1)C1CCN(CC1)c1ccc(Nc2nccc(n2)-c2ccc(cc2)C(=O)NCC#N)cc1

InChI Key InChIKey=YAPGULIZAFUFTB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 234958   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

US Patent
LigandPNGBDBM234958(US9556148, 25 | n-(cyanomethyl)-4-(2-((4-(4-(5-met...)
Affinity DataIC50:  12nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

US Patent
LigandPNGBDBM234958(US9556148, 25 | n-(cyanomethyl)-4-(2-((4-(4-(5-met...)
Affinity DataIC50:  8nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234958(US9556148, 25 | n-(cyanomethyl)-4-(2-((4-(4-(5-met...)
Affinity DataIC50:  48nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

US Patent
LigandPNGBDBM234958(US9556148, 25 | n-(cyanomethyl)-4-(2-((4-(4-(5-met...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

US Patent
LigandPNGBDBM234958(US9556148, 25 | n-(cyanomethyl)-4-(2-((4-(4-(5-met...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234958(US9556148, 25 | n-(cyanomethyl)-4-(2-((4-(4-(5-met...)
Affinity DataIC50:  48nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent