BDBM23802 2-[(triphenylmethyl)sulfanyl]ethan-1-amine::Triphenylmethyl-containing compound, 31

SMILES NCCSC(c1ccccc1)(c1ccccc1)c1ccccc1

InChI Key InChIKey=XZOWICPSVWHCTC-UHFFFAOYSA-N

Data  5 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 23802   

TargetKinesin-like protein KIF11(Homo sapiens (Human))
Institut De Biologie Structurale

LigandPNGBDBM23802(2-[(triphenylmethyl)sulfanyl]ethan-1-amine | Triph...)
Affinity DataKi:  150nM ΔG°:  -9.30kcal/moleT: 2°CAssay Description:The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Institut De Biologie Structurale

LigandPNGBDBM23802(2-[(triphenylmethyl)sulfanyl]ethan-1-amine | Triph...)
Affinity DataKi:  152nMAssay Description:Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Institut De Biologie Structurale

LigandPNGBDBM23802(2-[(triphenylmethyl)sulfanyl]ethan-1-amine | Triph...)
Affinity DataKi:  156nMAssay Description:Inhibition of C-terminal His6-tagged human Eg5 basal ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Institut De Biologie Structurale

LigandPNGBDBM23802(2-[(triphenylmethyl)sulfanyl]ethan-1-amine | Triph...)
Affinity DataKi:  245nMAssay Description:Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Institut De Biologie Structurale

LigandPNGBDBM23802(2-[(triphenylmethyl)sulfanyl]ethan-1-amine | Triph...)
Affinity DataKi:  246nMAssay Description:Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Institut De Biologie Structurale

LigandPNGBDBM23802(2-[(triphenylmethyl)sulfanyl]ethan-1-amine | Triph...)
Affinity DataIC50:  396nMAssay Description:Inhibition of C-terminal His6-tagged human Eg5 microtubule-stimulated ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Institut De Biologie Structurale

LigandPNGBDBM23802(2-[(triphenylmethyl)sulfanyl]ethan-1-amine | Triph...)
Affinity DataIC50:  241nMAssay Description:Inhibition of basal ATPase activity of Eg5 by coupled pyruvate kinase/lactate dehydrogenase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Science Farm

Curated by ChEMBL
LigandPNGBDBM23802(2-[(triphenylmethyl)sulfanyl]ethan-1-amine | Triph...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) using FAM-labeled RHKK(Ac) LM peptide as substrate incubated for 60 mins by electrophoretic mobility...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed