BDBM243402 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidine-2,4-diamine::US10053458, 34
SMILES COc1cc2CCNCc2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1
InChI Key InChIKey=ZTQDHDMZXGLFHJ-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 243402
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Research Institute of Chemical Technology
US Patent
Korea Research Institute of Chemical Technology
US Patent
Affinity DataIC50: 1nMT: 2°CAssay Description:A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor [L1196M](Homo sapiens (Human))
Korea Research Institute of Chemical Technology
US Patent
Korea Research Institute of Chemical Technology
US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Research Institute of Chemical Technology
US Patent
Korea Research Institute of Chemical Technology
US Patent
Affinity DataIC50: 1nMAssay Description:Inhibition of ALK (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescence assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Research Institute of Chemical Technology
US Patent
Korea Research Institute of Chemical Technology
US Patent
Affinity DataIC50: 0.450nMAssay Description:Inhibition of crizotinib-resistant ALK C1156Y mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Research Institute of Chemical Technology
US Patent
Korea Research Institute of Chemical Technology
US Patent
Affinity DataIC50: 7nMAssay Description:Inhibition of crizotinib-resistant ALK L1196M mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Research Institute of Chemical Technology
US Patent
Korea Research Institute of Chemical Technology
US Patent
Affinity DataIC50: 0.240nMAssay Description:Inhibition of crizotinib-resistant ALK G1269A mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Research Institute of Chemical Technology
US Patent
Korea Research Institute of Chemical Technology
US Patent
Affinity DataIC50: 0.460nMAssay Description:Inhibition of crizotinib-resistant ALK F1174L mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Research Institute of Chemical Technology
US Patent
Korea Research Institute of Chemical Technology
US Patent
Affinity DataIC50: 1.30nMAssay Description:Inhibition of crizotinib-resistant ALK G1202R mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...More data for this Ligand-Target Pair