BDBM244609 US10226449, cpd 295::US9428502, 218::US9428502, 295

SMILES Cc1nc(c([nH]1)-c1cc(ccc1C)C(=O)N1CC(C1)c1ccc(cc1)C#N)C(F)(F)F

InChI Key InChIKey=SLBIPTFGFMMHEE-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 244609   

TargetFatty acid synthase(Homo sapiens (Human))
3-V Biosciences

US Patent
LigandPNGBDBM244609(US10226449, cpd 295 | US9428502, 218 | US9428502, ...)
Affinity DataIC50:  15nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
3-V Biosciences

US Patent
LigandPNGBDBM244609(US10226449, cpd 295 | US9428502, 218 | US9428502, ...)
Affinity DataIC50:  31nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
3-V Biosciences

US Patent
LigandPNGBDBM244609(US10226449, cpd 295 | US9428502, 218 | US9428502, ...)
Affinity DataEC50:  37nMAssay Description:The antiviral activities of the compounds were assessed using the HCV1b replicon system. The replicon was constructed using the ET (luc-ubi-neo/ET) c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C Virus (Virus))
3-V Biosciences

US Patent
LigandPNGBDBM244609(US10226449, cpd 295 | US9428502, 218 | US9428502, ...)
Affinity DataEC50:  3nMAssay Description:The antiviral activities of the compounds were assessed using the HCV1b replicon system. The replicon was constructed using the ET (luc-ubi-neo/ET) c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
3-V Biosciences

US Patent
LigandPNGBDBM244609(US10226449, cpd 295 | US9428502, 218 | US9428502, ...)
Affinity DataIC50:  31nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
3-V Biosciences

US Patent
LigandPNGBDBM244609(US10226449, cpd 295 | US9428502, 218 | US9428502, ...)
Affinity DataIC50:  15nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent