BDBM24476 7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]triazolo[4,3-a]pyridazin-3-yl]methoxy}quinoline::Triazolopyridazine, 10f

SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(F)c(F)c(F)c3)ccnc2c1

InChI Key InChIKey=MLHUEVZLHPFKKC-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 24476   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24476(7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24476(7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24476(7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Affinity DataIC50:  8nMAssay Description:Inhibition of HGF-mediated MET autophosphorylation in human PC3 cells preincubated for 1 hr followed by stimulation with human HGF measured after 10 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM24476(7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24476(7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM24476(7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Affinity DataIC50:  5nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM24476(7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM24476(7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human CYP3A4 in human liver microsomes preincubated with NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM24476(7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) in absence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed