BDBM24949 3-(2-hydroxyethyl)-20-(propan-2-yloxy)-3,13-diazahexacyclo[14.8.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tetracosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20-nonaen-14-one::5-oxo dihydronaphthylcarbazole analogue, 16

SMILES CC(C)Oc1ccc-2c(CCc3c-2c2C(=O)NCc2c2c4ccccc4n(CCO)c32)c1

InChI Key InChIKey=HSWWFIPPMAFLPH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 24949   

TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Cephalon

LigandPNGBDBM24949(3-(2-hydroxyethyl)-20-(propan-2-yloxy)-3,13-diazah...)
Affinity DataIC50:  26nMpH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Cephalon

LigandPNGBDBM24949(3-(2-hydroxyethyl)-20-(propan-2-yloxy)-3,13-diazah...)
Affinity DataIC50:  65nMpH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

LigandPNGBDBM24949(3-(2-hydroxyethyl)-20-(propan-2-yloxy)-3,13-diazah...)
Affinity DataIC50:  3.38E+3nMAssay Description:Compounds were evaluated for their ability to inhibit the kinase activity using an ELISA-based assay. The 96-well microtiter plate is coated with sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Cephalon

LigandPNGBDBM24949(3-(2-hydroxyethyl)-20-(propan-2-yloxy)-3,13-diazah...)
Affinity DataIC50:  1.06E+3nMAssay Description:Compounds were evaluated for their ability to inhibit the kinase activity of TrkA using an ELISA-based assay. The 96-well microtiter plate is coated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 10(Homo sapiens (Human))
Cephalon

LigandPNGBDBM24949(3-(2-hydroxyethyl)-20-(propan-2-yloxy)-3,13-diazah...)
Affinity DataIC50:  1.86E+3nMAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed