BDBM251457 US9452998, 6

SMILES Nc1ncc(nc1C(=O)Nc1ncccc1N1CCC(N)(CO)CC1)-c1ncccc1OC(F)(F)F

InChI Key InChIKey=AAKDVUMRVXYBST-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 251457   

TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251457(US9452998, 6)
Affinity DataIC50:  0.220nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251457(US9452998, 6)
Affinity DataIC50:  1.30E+3nMpH: 7.0 T: 2°CAssay Description:Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC α/θ inhibition activity inclu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251457(US9452998, 6)
Affinity DataIC50:  2.10nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent