BDBM251474 US9452998, 23::US9452998, 86

SMILES CC1(N)CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1nc(ccc1F)C#N

InChI Key InChIKey=HLTRFCVVQYHUFQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 251474   

TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251474(US9452998, 23 | US9452998, 86)
Affinity DataIC50:  1.90nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251474(US9452998, 23 | US9452998, 86)
Affinity DataIC50:  3.90nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251474(US9452998, 23 | US9452998, 86)
Affinity DataIC50:  3.90nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM251474(US9452998, 23 | US9452998, 86)
Affinity DataIC50:  1.90nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent