BDBM25406 4-(2,4-dichlorophenoxy)-3-hydroxybenzoic acid::CHEMBL240808::Triclosan derivative, 7

SMILES OC(=O)c1ccc(Oc2ccc(Cl)cc2Cl)c(O)c1

InChI Key InChIKey=KUJXLYCFJYCPHN-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 25406   

TargetEnoyl-ACP reductase(Plasmodium falciparum)
Jacobus Pharmaceutical

LigandPNGBDBM25406(4-(2,4-dichlorophenoxy)-3-hydroxybenzoic acid | CH...)
Affinity DataIC50: >1.00E+5nMpH: 7.9 T: 2°CAssay Description:PfENR inhibition assays were carried out on a Cary 100 Bio Spectrophotometer or POLARstar Optima by monitoring oxidation of NADH at 340 nm. The IC50 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM25406(4-(2,4-dichlorophenoxy)-3-hydroxybenzoic acid | CH...)
Affinity DataIC50:  2.59E+3nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM25406(4-(2,4-dichlorophenoxy)-3-hydroxybenzoic acid | CH...)
Affinity DataKd:  27nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed