BDBM263751 2-fluoro-4- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-2- hydroxy- 8,9- dihydro- 7H- benzo[7]- annulen-6- yl]benzo- nitrile::US9714221, Example 85

SMILES Oc1ccc2c(CCCC(c3ccc(C#N)c(F)c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1

InChI Key InChIKey=BBEQQPWXVBUVFK-MHZLTWQESA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 263751   

TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263751(2-fluoro-4- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrro...)
Affinity DataIC50:  58nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263751(2-fluoro-4- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrro...)
Affinity DataIC50:  735nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [D538G](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263751(2-fluoro-4- 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrro...)
Affinity DataIC50:  1.11E+3nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent