BDBM26515 1-[4-(cyclopentylamino)-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl]ethan-1-one::BI 2536 analogue, 2a

SMILES COc1cc(ccc1Nc1ncc(C(C)=O)c(NC2CCCC2)n1)N1CCN(C)CC1

InChI Key InChIKey=RLQUSJKLICEKBP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26515   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM26515(1-[4-(cyclopentylamino)-2-{[2-methoxy-4-(4-methylp...)
Affinity DataIC50:  145nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM26515(1-[4-(cyclopentylamino)-2-{[2-methoxy-4-(4-methylp...)
Affinity DataIC50:  2.58E+3nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM26515(1-[4-(cyclopentylamino)-2-{[2-methoxy-4-(4-methylp...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed