BDBM26820 BMCL186218 Compound 1::CHEMBL457886::N-[(2E)-5-[benzene(methyl)amido]-1-(2-carbamoylethyl)-2,3-dihydro-1H-1,3-benzodiazol-2-ylidene]thiophene-2-carboxamide::acylated 2-aminobenzimidazole, 14

SMILES CN(C(=O)c1ccccc1)c1ccc2n(CCC(N)=O)c(NC(=O)c3cccs3)nc2c1

InChI Key InChIKey=ILVXQPRFMVXZRH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 26820   

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26820(BMCL186218 Compound 1 | CHEMBL457886 | N-[(2E)-5-[...)
Affinity DataIC50:  58nMpH: 7.0 T: 2°CAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26820(BMCL186218 Compound 1 | CHEMBL457886 | N-[(2E)-5-[...)
Affinity DataIC50:  150nMAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26820(BMCL186218 Compound 1 | CHEMBL457886 | N-[(2E)-5-[...)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant ITK (unknown origin) by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26820(BMCL186218 Compound 1 | CHEMBL457886 | N-[(2E)-5-[...)
Affinity DataIC50:  145nMAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26820(BMCL186218 Compound 1 | CHEMBL457886 | N-[(2E)-5-[...)
Affinity DataIC50:  110nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM26820(BMCL186218 Compound 1 | CHEMBL457886 | N-[(2E)-5-[...)
Affinity DataIC50:  25nMpH: 7.0 T: 2°CAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed