BDBM28757 2-methyl-2-[2-methyl-4-({3-[4-(trifluoromethoxy)phenyl]-1,2,4-thiadiazol-5-yl}methoxy)phenoxy]propanoic acid::oxygen-link [1,2,4]thiadiazole derivative, 51

SMILES Cc1cc(OCc2nc(ns2)-c2ccc(OC(F)(F)F)cc2)ccc1OC(C)(C)C(O)=O

InChI Key InChIKey=NWOQGTFCVBLDHG-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 28757   

TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM28757(2-methyl-2-[2-methyl-4-({3-[4-(trifluoromethoxy)ph...)
Affinity DataEC50:  94nMAssay Description:The HEK293 cells were co-transfected with DNA constructs containing the ligand-binding domain of PPAR and Gal4-luciferase reporter. The luciferase ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM28757(2-methyl-2-[2-methyl-4-({3-[4-(trifluoromethoxy)ph...)
Affinity DataEC50: >3.00E+3nMAssay Description:The HEK293 cells were co-transfected with DNA constructs containing the ligand-binding domain of PPAR and Gal4-luciferase reporter. The luciferase ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM28757(2-methyl-2-[2-methyl-4-({3-[4-(trifluoromethoxy)ph...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM28757(2-methyl-2-[2-methyl-4-({3-[4-(trifluoromethoxy)ph...)
Affinity DataEC50: >3.00E+3nMAssay Description:Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM28757(2-methyl-2-[2-methyl-4-({3-[4-(trifluoromethoxy)ph...)
Affinity DataEC50:  94nMAssay Description:Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM28757(2-methyl-2-[2-methyl-4-({3-[4-(trifluoromethoxy)ph...)
Affinity DataEC50:  12nMAssay Description:The confluent HEK293 cells were co-transfected with DNA construct containing PPARdelta-Gal4 chimeric receptor and Gal4-luciferase reporter. The lucif...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed