BDBM29588 CHEMBL226779::isatin Michael acceptor (IMA) analogue, 3

SMILES O=[#6]1-[#7](-[#6]-c2ccccc2)-c2ccc(cc2\[#6]-1=[#6](\C#N)C#N)S(=O)(=O)[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6]-[#8]-c1ccccc1

InChI Key InChIKey=CNRQFHSEEJMLKI-QHCPKHFHSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 29588   

TargetCaspase-6(Homo sapiens (Human))
Washington University

LigandPNGBDBM29588(CHEMBL226779 | isatin Michael acceptor (IMA) analo...)
Affinity DataIC50:  918nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University

LigandPNGBDBM29588(CHEMBL226779 | isatin Michael acceptor (IMA) analo...)
Affinity DataIC50:  27.8nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Washington University

LigandPNGBDBM29588(CHEMBL226779 | isatin Michael acceptor (IMA) analo...)
Affinity DataIC50:  918nMAssay Description:Inhibition of human recombinant caspase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM29588(CHEMBL226779 | isatin Michael acceptor (IMA) analo...)
Affinity DataIC50:  51.7nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM29588(CHEMBL226779 | isatin Michael acceptor (IMA) analo...)
Affinity DataIC50:  6.22E+3nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University

LigandPNGBDBM29588(CHEMBL226779 | isatin Michael acceptor (IMA) analo...)
Affinity DataIC50:  27.8nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM29588(CHEMBL226779 | isatin Michael acceptor (IMA) analo...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed