BDBM299616 N6-(pyrazin-2- ylmethyl)pyrido [3,2-d]pyrimidine- 4,6-diamine::US9592235, Example 362::US9855269, Compound 258

SMILES Nc1ncnc2ccc(NCc3cnccn3)nc12

InChI Key InChIKey=PSBMVQSLMCTROX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299616   

TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM299616(N6-(pyrazin-2- ylmethyl)pyrido [3,2-d]pyrimidine- ...)
Affinity DataIC50:  4.80E+3nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM299616(N6-(pyrazin-2- ylmethyl)pyrido [3,2-d]pyrimidine- ...)
Affinity DataIC50:  4.80E+3nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent